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Only your doctor can determine if it is safe for you to continue taking Avandia. People taking Avandia were sicker than those taking Actos, so these patients were more likely to develop heart failure, she noted. Since insulin shots are known to be safe, your doctor may switch you from Avandia to insulin until the baby is born. Food and Drug Administration convened an expert panel in July to consider the heart-attack risk associated with Avandia. Clifford Rosen, of the Maine Center for Osteoporosis, who headed the recent FDA advisory committee panel that recommended Avandia stay on the market, albeit with stronger warnings. The Medication Guide and current Prescribing Information for Avandia are provided below. Because many drugs do find their way into breast milk, however, the safest bet is to avoid taking Avandia while nursing. Nor can Avandia relieve diabetic ketoacidosis (excessively high sugar levels due to lack of insulin). "Across the extensive dataset for Avandia, GlaxoSmithKline believes there is no consistent or systematic evidence that Avandia increases the risk of heart attack or cardiovascular death in comparison to other anti-diabetic medicines," the company said in a prepared statement. Nissen, chairman of the Cleveland Clinic's department of cardiovascular medicine, reported a 43 percent increased risk of heart attack among patients taking Avandia (generic name rosiglitazone). Avandia should be avoided by anyone who has been diagnosed with heart failure, and it should be discontinued by anyone who develops it. However, the maximum recommended dose of Avandia in combination with insulin or a sulfonylurea diabetes drug is 4 milligrams per day. It is especially important to check with your doctor before combining Avandia with other drugs or supplements that can lower blood sugar levels. Avandia has already been linked to an increased risk of heart failure. Glucovance can also be combined with other diabetes drugs such as Avandia. Remember, too, that Avandia is not an oral form of insulin, and cannot be used in place of insulin. 18 -- The type 2 diabetes drug Avandia (rosiglitazone) increases the risk of heart failure and death more than another drug in the same class, Actos (pioglitazone), new Canadian research contends. You should not take Avandia if you have liver problems. Avandia works first by decreasing sugar production, then by helping the body make more efficient use of whatever insulin is available. Steven Nissen, chairman of the Department of Cardiovascular Medicine at the Cleveland Clinic, published a study that found Avandia showed a 43 percent greater risk of heart attack among diabetes patients, and he remains convinced that the drug should not be used. Avandia is used to treat the following conditions: Diabetes, Type 2, Nonalcoholic Fatty Liver Disease. 75 events per 100 patient years for use of Avandia(R) vs. The FDA has requested that Avandia's maker, GlaxoSmithKline, strengthen its warning about heart-failure risk. 8 -- The debate over the heart-attack risks posed by the type 2 diabetes drug Avandia has taken another twist, with a new study questioning the results of the research that kick-started the controversy. If Avandia is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Your doctor will check to make sure your liver function is normal before prescribing Avandia, then recheck it every 2 months for the first 12 months and periodically thereafter. In the case of Avandia, researchers focused on the durability of the patients' blood sugar control ("glycemic durability", even though blood sugar control is "a relatively poor surrogate for cardiovascular outcomes in type 2 diabetes," Rosen said.



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